INDEX
Articles: 2022 / 2021 / 2020 / 2019 / 2018 / 2017 / 2015 / 2014 / 2013 / 2012 / 2011 / 2010 / 2009 / 2008 / 2007 / 2006 / 2005 / 2004 / 2003 / 2002 / 2001 / 2000 / ~1999 / 1977
International Meetings
Articles [Latest Publication List]
2022
Achievements of Kawato's Lab have received high evaluations, as published in several review papers.

Azcoitia I, Hernandez-Vivanco A, Cano-Adamuz N and Mendez P
Synthesis and impact of neuroestradiol on hippocampal neuronal networks
Current Opinion in Endocrine and Metabolic Research(2022) Vol. 24, 100335 [PDF]

Garcia-Segura LM, Mendez P, Arevalo MA, Azcoitia I
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Frontiers in Neuroendocrinology(2023) Vol. 71, 101102 [PDF]
2021
Kawato S, Ogiue-Ikeda M, Soma M, Yoshino H, Kominami T, Saito M, Aou S and Hojo Y
Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-up Adult Hippocampal Neurons
Frontiers in Neuroscience (2021), Vol 15 , Article 712261 [PDF]
2020
Kato A, Murakami G, Hojo Y, Horie S and Kawato S
Rapid effects of estradiol on dendritic spines and synaptic plasticity in the male and female hippocampus
Estrogens and Memory: Basic Research and Clinical Implications
Oxford Univ. Press (2020), Chapter 3, pp38-47, Edited by Karyn M. Frick [PDF]
ISBN: 9780190645908
2019
Murakami G and Kawato S
Co-Immunoprecipitation Methods to Identify Associated Proteins with Estrogen Receptor a at Postsynaptic Density in Brain Tissue
Neuromethods (2019) vol. 144, 9-21 [PDF]
Tozzi A, Durante V, Manca P, Di Mauro M, Blasi J, Grassi S, Calabresi P, Kawato S, Pettorossi VE
Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal
CA1 Pyramidal Neurons
Front Cell Neurosci (2019) 13 Article 534
doi: 10.3389/fncel.2019.00534. eCollection 2019. [PDF]
2018
Kitamura A, Hojo Y, Ikeda M, Karakawa S, Kuwahara T, Kim J, Soma M, Kawato S and Tsurugizawa T
Ingested D-aspartate facilitates the functional connectivity and modifies dendritic spine morphology in rat hippocampus
Cerebral Cortex (2018) 1-10
doi: 10.1093/cercor/bhy120 [PDF]
Hojo Y and Kawato S
Neurosteroids in adult hippocampus of male and female rodents: biosynthesis and actions of sex steroids
Frontiers in Endocrinology Research Topic "Steroids and the Brain" (2018) Vol. 9, Article 183
doi: 10.3389/fendo.2018.00183 [PDF], 66 citations
Soma M, Kim J, Kato A and Kawato S
Src kinase dependent rapid non-genomic modulation of hippocampal spinogenesis induced by androgen and estrogen
Frontiers in Neuroscience Research Topic "Steroids and the Brain" (2018) Vol. 12, Article 282
doi: 10.3389/fnins.2018.00282 [PDF], 19 citations
Ide H, Lu Y, Noguchi T, Muto S, Okada H, Kawato S and Horie S
Modulation of AKR1C2 by Curcumin Decreases Testosterone Production in Prostate Cancer
Cancer Science (2018) 109, 1230-1238.
DOI: 10.1111/cas.13517 [PDF], 31 citations
Murakami G, Hojo Y, Kato A, Komatsuzaki Y, Horie S, Soma Mika, Kim J and Kawato S
Rapid non-genomic modulation by neurosteroids of dendritic spines in the hippocampus: androgen, estrogen and corticosteroid
J. Neuroendocrinol (2018) 30, Issue 2 [PDF]
DOI: 10.1111/jne.12561, 35 citations
2017
Ishihara Y, Itoh K, Tanaka M, Tsuji M, Kawamoto T, Kawato S, Vogel C and Yamazaki T
The potentiation of the synthesis of 17 -estradiol in the brain and the elongation of seizure latency by dietary supplementation with docosahexaenoic acid
Scientific Reports (2017) 7, Article number: 6268 doi :10.1038/s41598-017-06630-0
[PDF], 20 citations
Ide H, Lu Y, Yu J, Noguchi T, Kanayama M, Muto S, Yamaguchi R, Kawato S, Horie S
Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells
Human cell (2017) 30,133-139, 19 citations
Ooishi Y, Mukai H, Watanabe K, Kawato S, Kashino M
Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music.
PLoS ONE (2017) 12: e0189075. [PDF]
2015
Ikeda M, Hojo Y, Komatsuzaki Y, Okamoto M, Kato A, Takeda T and Kawato S
Hippocampal spine change along the sleep-wake cycle: corticosterone and kinases
J. Endocrinol Special Issue "60 years of neuroendocrinology" (2015) 226, M13-M27
doi.org/10.1530/JOE-15-0078 [PDF]
, 45 citations [British Society for Endocrinology Journal Awards 2016]
Hojo Y, Munetomo A, Mukai H, Ikeda M, Sato R, Hatanaka Y, Murakami G, Komatsuzaki Y, Kimoto T and Kawato S
Estradiol Rapidly Modulates Spinogenesis in Hippocampal Dentate Gyrus: Involvement of Kinase Networks
Hormones and Behavior Special Issue "Estradiol and cognitive function" (2015) 74, 149-156
doi.org/10.1016/j.yhbeh.2015.06.008 [PDF], 33 citations
Hasegawa Y, Hojo Y, Kojima H, Ikeda M, Hotta K, Sato R, Yoshiya M, Chung BC, Ooishi Y, and Kawato S
Estradiol Rapidly Modulates Synaptic Plasticity of Hippocampal Neurons: Involvement of Kinase Networks
Brain Res. Special Issue "Brain and Memory" (2015) 1621, 147-161
doi.org/10.1016/j.brainres.2014.12.056 [PDF], 92 citations (IF 8)
Murakami G, Hojo Y, Ogiue-Ikeda M, Mukai H, Chambon P, Nakajima K, Ooishi Y, Kimoto T and Kawato S
Estrogen Receptor KO Mice Study on Rapid Modulation of Spines and Long-term Depression in the Hippocampus
Brain Res. Special Issue "Brain and Memory" (2015) 1621, 133-146
doi.org/10.1016/j.brainres.2014.12.002 [PDF], 48 citations (IF 8)
[Appendix A. Supplementary materials]
Hatanaka Y, Hojo Y, Mukai H, Murakami G, Komatsuzaki Y, Kim J, Ikeda M, Hiragushi A, Kimoto T, and Kawato S
Rapid increase of spines by dihydrotestosterone and testosterone in hippocampal neurons: Dependence on synaptic androgen receptor and kinase networks
Brain Res. Special Issue "Brain and Memory" (2015) 1621, 121-132
doi.org/10.1016/j.brainres.2014.12.011 [PDF], 83 citations (IF 8)
Munetomo A, Hojo Y, Higo S, Kato A, Yoshida K, Shirasawa T, Shimizu T, Barron A, Kimoto T and Kawato S
Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors incortex, hypothalamus and cerebellum
J Physiol. Sci (2015) 65, 253-263
dx.doi.org/10.1007/s12576-015-0363-x [PDF], 33 citations
2014
Hasegawa Y, Mukai H, Asashima M, Hojo Y, Ikeda M, Komatsuzaki Y, Ooishi Y, Kawato S
Acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus
Front. Neural Circuits (2014) Vol 8, Article 56
dx.doi.org/10.3389/fncir.2014.00056 [PDF], 28 citations
Hojo Y, Okamoto M, Kato A, Higo S, Sakai S, Soya H, Yamazaki Y and Kawato S
Neurosteroid synthesis in adult female rat hippocampus, including androgens and allopregnanolone
Journal of Steroids & Hormonal Science (2014) Article S4: 002
[PDF]
2013
Yoshiya M, Komatsuzaki Y, Ikeda M, Hojo Y, Mukai H, Hatanaka Y,Murakami G, Kawata M, Kimoto T and Kawato
Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus
Front. Neural Circuits (2013) Vol 7, Article 191 [PDF], 36 citations
Kato A, Hojo Y, Higo S, Komatsuzaki Y, Murakami G, Yoshino H, Uebayashi M, Kawato S
Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines
Front Neural Circuits. (2013) Vol 7, Article 149 [PDF], 157 citations
Hasegawa Y, Ogiue-Ikeda M, Tanabe N, Kimoto T, Hojo Y, Yamazaki T, Kawato S
Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multi-electrode system
Neuro Endocrinol Lett. (2013) 34, 129-134 [PDF]
Yamazaki T, Yamamoto M, Ishihara Y, Komatsu S, Munetsuna E, Onizaki M, Ishida A, Kawato S, Mukuda T
De novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices
PLoS ONE (2013) 8:e55559 [PDF], 20 citations
2012
Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen B, Soya H
Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis
Proc. Natl. Acad. Sci. U.S.A. (2012) 109, 13100-13105 [PDF] [An article published in the New York Times], 143 citations
Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S
Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus
PLoS one (2012) 7:e34124 [PDF], [Supple], 71 citations
Tanabe N, Yoshino H, Kimoto T, Hojo Y, Ogiue-Ikeda M, Shimohigashi Y, Kawato S
Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons
Mol Cell Endocrinol. (2012) 351, 317-325 [PDF], 29 citations
Ooishi Y, Kawato S, Hojo Y, Hatanaka Y, Higo S, Mukai H, Murakami G, Ogiue-Ikeda M, Kimoto T
Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen
J Steroid Biochem Mol Biol (2012) 131, 37-51 [PDF], 127 citations
Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y, Shindo T, Morrison JH, Kimoto T, Kawato S
Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear Steroid Receptors in the Hippocampus
Cerebral Cortex (2012) 4, 926-936 [PDF], 36 citations
2011
Osanai H, Suzuki A, Komatsuzaki Y, Mukai H, Kawato S, Saito M
The binding site for acute corticosterone effects on N-methyl-D-aspartate receptor-mediated Ca2+ signals in mouse hippocampal slices
Journal of Biophysical Chemistry (2011) Vol 2, 430-433 [PDF]
Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T
Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity
Front Neuroendocrine Science (2011) Vol 2, Article 43 [PDF], 83 citations
Barron A, Hojo Y, Muka H, Higo S, Ooishi Y, Hatanaka Y, Ogiue-Ikeda M, Murakami G, Kimoto T, Kawato S
Regulation of synaptic plasticity by hippocampus synthesised estradiol
Hormone Mol Biol and Clinic Invest, Special issue Hormones and the Brain (2011) 7, 361-375 [PDF]
Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Anna B, Kimoto T, Kawato S
Endogenous Synthesis of Corticosteroids in the Hippocampus
PLoS One (2011) 6:e21631 [PDF], 37 citations
Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Komatsuzaki Y, Sato R, Murakami G, Kimoto T, Kawato S
Automated analysis of spines from confocal laser microscopy images: application to the discrimination of androgen and estrogen effects on spinogenesis
Cerebral Cortex (2011) 21:2704-2711, Open Access [PDF] [MOVIE]
Spiso program obtains a U.S. Patent. [PDF]
Spine analysis software "Spiso-3D" can be downloaded.
>>[Manual],[Full Spiso-3D], 45 citations
2010
Mukai H, Kimoto T, Hojo Y, Kawato S, Murakami G, Higo S, Hatanaka Y, Ogiue-Ikeda M
"Modulation of synaptic plasticity by brain estrogen in the hippocampus"
Biochim. Biophys. Acta Special Issue "Estrogen in the Brain" (2010) 1800, 1030-1044 [PDF], 156 citations
appeared in the cover page[PDF], 111 citations
Kimoto T, Ishii H, Higo S, Hojo Y, Kawato S
"Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus"
Endocrinology (2010) 151, 5795-5806 [PDF], 50 citations
2009
Hojo Y, Higo S, Ishii H, Ooishi Y, Mukai H, Murakami G, Kominami T, Kimoto T, Honma S, Poirier D, Kawato S
"Comparison between Hippocampus-Synthesized and Circulation-Derived Sex Steroids in the Hippocampus"
Endocrinology (2009) 150, 5106-5112 [PDF], 162 citations
Munetsuna E, Hattori M, Komatsu S, Sakimoto Y, Ishida A, Sakata S, Hojo Y, Kawato S, Yamazaki T
"Social isolation stimulates hippocampal estradiol synthesis"
Biochem. Biophys. Res. Commun. (2009) 379, 480-484 [PDF], 28 citations
Munetsuna E, Hojo Y, Hattori M, Ishii H, Kawato S, Ishida A, Kominami S, Yamazaki T
"Retinoic Acid Stimulates 17β-Estradiol and Testosterone Synthesis in Rat Hippocampal Slice Cultures"
Endocrinology. (2009) 150, 4260-4269 [PDF] [Suppl], 80 citations
Kimoto T, Yamada M, Ichikawa T, Honma D, Cherry RJ, Morrison IE, Kawato S
"Digital fluorescence analysis of trafficking of single endosomes containing low-density lipoprotein in adrenocortical cells: Facilitation of centripetal motion by adrenocorticotropic hormone"
Mol Cell Endocrinol. (2009) 307, 185-195 [PDF]
Higo S, Hojo Y, Ishii H, Kominami T, Nakajima K, Poirier D, Kimoto T, Kawato S
"Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus"
Biochem. Biophys. Res. Commun. (2009) 385, 62-66 [PDF], 28 citations [Suppl]
Hatanaka Y, Mukai H, Mitsuhashi K, Hojo Y, Murakami G, Komatsuzaki Y, Sato R, Kawato S
"Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus"
Biochem. Biophys. Res. Commun. (2009) 381, 728-732 [PDF], 82 citations
Fujita C, Ichikawa F, Teratatni T, Murakami G, Okada T, Shinohara M, Kawato S, Ohta Y
"Direct effects of corticosterone on ATP production by mitochondria from immortalized hypothalamic GT1-7 neurons"
J. Steroid Biochem. Mol. Biol. (2009) 117, 50-55 [PDF], 18 citations
2008
Hojo Y, Murakami G, Mukai H, Higo S, Hatanaka Y, Ogiue-Ikeda M, Ishii H, Kimoto T, Kawato S
"Estrogen synthesis in the brain-Role in synaptic plasticity and memory"
Mol Cell Endocrinol. (2008) 290, 31-43 [PDF], 231 citations
Kawato S, Hojo Y, Mukai H, Murakami G, Ogiue-Ikeda M, Ishii H, Kimoto T
"Local Production of Estrogen and its Rapid Modulatory Action on Synaptic Plasticity"
Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders (2008), 143-169
Ogiue-Ikeda M, Tanabe N, Mukai H, Hojo Y, Murakami G, Tsurugizawa T, Takata N, Kimoto T, Kawato S
"Rapid Modulation of Synaptic Plasticity by Estrogens as well as Endocrine Disrupters in Hippocampal Neurons"
Brain Res Rev. (2008) 57, 363-375 [PDF], 150 citations
2007
Komatsuzaki Y, Kawato S
"Rapid Effect of Progesterone on the Intracellular Ca2+ Oscillation of Immortalized Hypothalamic GT1-7 Cells"
Bioimages (2007) 15, 1-7 [PDF]
Ishii H, Tsurugizawa T, Ogiue-Ikeda M, Asashima M, Mukai H, Murakami G, Hojo Y, Kimoto T. Kawato S
"Local Production of Sex Hormones and Their Modulation of Hippocampal Synaptic Plasticity"
The Neuroscientist (2007) 13, 323-334 [PDF], 82 citations
Mukai H, Tsurugizawa T, Murakami G, Kominami S, Ishii H, Ogiue-Ikeda M, Takata N, Tanabe N, Furukawa A, Hojo Y, Ooishi Y, Morrison J.H, Janssen J. G.M, Rose J.A, Chambon P, Kato S, Izumi S, Yamazaki T, Kimoto T, Kawato S
"Rapid Modulation of Long-term Depression and Spinogenesis via Synaptic Estrogen Receptors in Hippocampal Principal Neurons "
J. Neurochem. (2007) 100, 950-967 [PDF], 242 citations
2006
Murakami G, Tsurugizawa T, Hatanaka Y, Komatsuzaki Y, Tanabe N, Mukai H, Hojo Y, Kominam S, Yamazaki T, Kimoto T, Kawato S
"Comparison between Basal and Apical Dendritic Spines in Estrogen-Induced Rapid Spinogenesis of CA1 Principal Neurons in the Adult Hippocampus"
Biochem. Biophys. Res. Commun. (2006) 351, 553-558 [PDF], 104 citations
Mukai H, Tsurugizawa T, Ogiue-Ikeda M, Murakami G, Hojo Y, Ishii H, Kimoto T, Kawato S
"Local neurosteroid production in the hippocampus: influence for synaptic plasticity of memory"
Neuroendocrinology (2006) 84, 255-263 [PDF], 130 citations
appeared in the cover page[img], 128 citations
Murakami G, Tanabe N, Ishii H, Ogiue-Ikeda M, Tsurugizawa T, Mukai H, Hojo Y, Takata N, Furukawa A, Kimoto T, Kawato S
"Role of Cytochrome P450 in Synaptocrinology: Endogenous Estrogen Synyhesis in The Brain Hippocampus"
Drug Metabolism Reviews (2006) 38, 353-369 [PDF], 36 citations
Tanabe N, Kimoto T, Kawato S
"Rapid Ca2+ signaling induced by Bisphenol A in cultured rat hippocampal neurons"
Neuro Endocrinol Lett. (2006) 27, 97-104 [PDF], 43 citations
Ishii H, Shibuya K, Ohta Y, Mukai H, Uchino S, Takata N, Rose J, Kawato S
"Enhancement of NO production by association of nitric oxide synthase with NMDA receptors via PSD-95 in genetically engineered CHO cells: real-time fluorescence imaging using NO sensitive dye"
J. Neurochem. (2006) 96, 1531-1539 [PDF], 38 citations
Mukai H, Takata N, Ishii H, Tanabe N, Hojo Y, Furukawa A, Kimoto T, Kawato S
"Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology"
Neuroscience (2006) 138, 757-764 [PDF], 145 citations
2005
Tsurugizawa T, Mukai H, Tanabe N, Murakami G, Hojo Y, Kominami S, Mitsuhashi K, Komatsuzaki Y, Morrison JH, Janssen WG, Kimoto T, Kawato S
"Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus"
Biochem. Biophys. Res. Commun. (2005) 337, 1345-52 [PDF], 59 citations
Komatsuzaki Y, Murakami G, Tsurugizawa T, Mukai H, Tanabe N, Mitsuhashi K, Kawata M, Kimoto T, Ooishi Y, Kawato S
"Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus"
Biochem. Biophys. Res. Commun. (2005) 335, 1002-1007 [PDF], 89 citations
Ogiue-Ikeda M, Kawato S, Ueno S
"Acquisition of ischemic tolerance by repetitive transcranial magnetic stimulation in the rat hippocampus"
Brain Res. (2005) 1037, 7-11 [PDF], 80 citations
Takata N, Harada T, Rose J.A, Kawato S
"Spatiotemporal analysis of NO production upon NMDA and tetanic stimulation of the hippocampus"
Hippocampus (2005) 15, 427-440 [PDF], 18 citations
2004
Shimizu M, Nakano Y, Yamasaki T, Kimoto T, Kawato S, Tamura H
"Region- and Isoform-Specific Expression of Hydroxysteroid Sulfotransferase in Rat Brain"
J. Health Sci. (2004) 50, 689-92 [PDF]
Sato S, Osanai H, Monma T, Harada T, Hirano A, Saito M, Kawato S
"Acute effect of corticosterone on N-methyl-D-aspartate receptor-mediated Ca2+ elevation in mouse hippocampal slices"
Biochem. Biophys. Res. Commun. (2004) 321, 510-513 [PDF], 62 citations
Kawato S
"Endocrine disrupters as disrupters of brain function: a neurosteroid view-point."
Environ. Sci. (2004) 11, 1-14 [PDF], 69 citations
Hojo Y, Hattori T, Enami T, Furukawa A, Suzuki K, Ishii H, Morrison J.H, Janssen W. G.M, Mukai H, Kominami S, Harada N, Kimoto T, and Kawato S
"Adult Male Rat Hippocampus Synthesizes Estradiol from Pregnenolone by Cytochromes P45017a and P450 Aromatase Localized in Neurons"
Proc. Natl. Acad. Sci. U.S.A. (2004) 101, 865-870 [PDF], 716 citations
2003
Ogiue-Ikeda M., Kawato S., Ueno S.
"The effect of repetitive transcranial magnetic stimulation on long-term potentiation in rat hippocampus depends on stimulus intensity."
Brain Res. (2003) 993, 222-226 [PDF], 114 citations
Ogiue-Ikeda M., Kawato S., Ueno S.
"The Effect of transcranial magnetic stimulation on long-term potentiation in rat hippocampus."
IEEE Trans. Magn. (2003) 39, 3390-3392 [PDF], 20 citations
Shibuya K., Takata N., Hojo Y., Furukawa A., Yasumatsu N., Kimoto T., Enami, Suzuki K., Tanabe N., Ishii H., Mukai H., Takahashi T., Hattori T., and Kawato S.
"Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction"
Biochim. Biophys. Acta (2003) 1619, 301-316 [PDF], 160 citations
Kawato S., Yamada M., and Kimoto T.
"Brain neurosteroids are 4th generation neuromessengers: Cell biophysical analysis of steroid signal transduction"
Adv. Biophys. (2003) Vol.37, 1-48, Japan Scientific Societies Press, Tokyo. [PDF], 84 citations
2002
Kimoto T., Tsurugizawa T., Ohta Y., Makino J., Tamura H-o, Hojo Y., Enami T., Kawato S.
"Cytochrome P450-dependent neurosteroid synthesis in the rat brain hippocampal neurons"
Oxygenases, Oxidases and Lipid Mediators (2002) 127-137, Elsevier, Tokyo, Japan
Takahashi T., Kimoto T., Tanabe N., Hattori T., Yasumatsu N., and Kawato S.
"Corticosterone acutely prolonged N-methyl-D-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons"
J. Neurochem. (2002) 83, 1441-1451 [PDF], 193 citations
Kawato S., Hojo Y., and Kimoto T.
"Histological and Metabolism Analysis of P450 in Brain"
Methods in Enzymol. (2002) Vol. 357, 241-249 (E. F. Johnson and M. R. Waterman, Eds). [PDF], 66 citations
Takata N., Shibuya K., Okabe M., Nagano T., Kojima H., and Kawato S.
"Pregnenolone sulfate acutely enhances NO production in the rat hippocampus: digital fluorescence study using NO reactive dye"
Bioimages (2002), 10, 1-8. [PDF]
2001
Kimoto T., Tsurugizawa T., Ohta Y., Makino J., Tamura H., Hojo Y., Takata N. and Kawato S.
"Neurosteroid Synthesis by Cytochrome P450-containing Systems Localized in the Rat Brain Hippocampal Neurons: N-Methyl-D-Aspartate and Calcium-dependent Synthesis"
Endocrinology(2001) 142, 3578-3589. [PDF], 291 citations
Yamada M., Ohta Y., Bachmanova G.I., Archakov A.I., Hatta I. and Kawato S.
"Effect of Microsome-Liposome Fusion on the Rotational Mobility of Cytochrome P450IIB4 in Rabbit Liver Microsomes"
J. Inorg. Chem.(2001) 83, 261-8
2000
Homma R., Kimoto T., Niimura Y., Krivosheev A., Hara T., Ohta Y., and Kawato S.
"Real-Time Fluorescence Analysis on Molecular Mechanisms for Regulation of Cytochrome P450scc Activity Upon Steroidogenic Stimulation in Adrenocortical Cells"
J. Inorg. Chem.(2000) 82, 171-180
Mukai H., Uchino S. and Kawato S.
"Effects of neurosteroids on Ca2+ signaling mediated by recombinant NMDA receptor expressed in CHO cells"
Neurosci. Lett.(2000), 282, 93-96 [PDF], 35 citations
Ichikawa T., Yamada M., Honma D., Cherry R. J., Morrison I. E. G. and Kawato S.
"Digital fluorescence imaging of trafficking of endosomes containing low density lipoprotein in brain astroglial cells"
Biochem. Biophys. Res. Commun.(2000) 269, 25-30 [PDF], 31 citations
~1999
Kawato S, Kimoto T, Ohta Y, Tsurugizawa T, Makino J, and Takahashi T
Localization and activities of neurosteroidogenic systems in the hippocampal neurons
Molecular Steroidogenesis (1999) 385-388 [PDF]
Yamada M., Ohta Y., Sakaki T., Yabusaki Y., Ohkawa H., and Kawato S.
"Dynamic mobility of genetically expressed fusion protein between cytochrome P4501A1 and NADPH-cytochrome P450 reductase in yeast microsomes"
Biochemistry (1999), 38, 9465-9470 [PDF]
Suzuki-Tomii K., Ohta Y., Kawato S., and Mitaku S.
"Comparative experiments of protein denaturation for studying structural difference of homologous membrane proteins: P-450scc and P-45011β"
Jpn. J. Appl. Phys. (1999), 38, 298-301 [PDF]
Yoshimura K., Sakurai Y., Nishimura D., Tsuruo Y., Nomura M., Kawato S., Seiwa C., Iguchi T., Itoh K., and Asou H.
"Monoclonal antibody 14F7, which recognizes a stage-specific immature oligodendrocyte surface molecule, inhibits oligodendrocyte differentiation mediated in co-culture with astrocytes"
J. Neurosci. Res. (1998), 54, 79-96 [PDF]
Yamazaki T., Kimoto T., Higuchi K., Ohta Y., Kawato S., and Kominami S.
"Calcium ion as a second messenger for o-nitrophenylsulfenyl-adrenocorticotropin (NPS-ACTH) and ACTH in bovine adrenal steroidogenesis"
Endocrinology (1998), 139, 4765-4771 [PDF], 51 citations
Kimoto T., Ohta Y. and Kawato S.
"Heterogeneous Populations of Adrenal Fasciculata Cells Examined with Ca2+ Signaling and Immunostaining: Single Cell Imaging"
Bioimages (1997), 5,133-142
Homma R., Kouyama T., Yamada M., Niimura Y., Krivosheev A., Hara T. and Kawato S.
"Time-resolved Study of Effect of Chlorpromazine on Mobility of Cytochrome P450 and Phospholipids in the Inner Membrane of Adrenocortical Mitochondria"
J. Pharm. Med. Anal. (1997), 15, 1215-1222
T. Kimoto, H. Asou, Y. Ohta, H. Mukai, A. Chernogolov and S. Kawato
"Digital Fluorescence Imaging of Elementary Steps of Neurosteroid Synthesis in Rat Brain Glial Cells"
J. Pharm. Med. Anal. (1997), 15, 1231-1240, 25 citations
T. Kimoto, H. Mukai, R. Homma, T. Bettou, D. Nishimura, Y. Ohta, and S. Kawato
"Imaging of Calcium Oscillations and Activity of Cytochrome P-450scc in Adrenocortical Cells"
Oxigen Homeostasis and Its Dynamics, Keio University Simposia for Life Science and Medicine Vol. 1, (Y. Ishimura, H. Shimada, and M. Suematsu Eds.) (1997), 252-259
T. Kimoto, Y. Ohta, and S. Kawato
"Adrenocorticotropin induces Calcium Oscillations in Adrenal Fasciculata Cells: Single Cell Imaging"
Biochem. Biophys. Res. Comm. (1996), 221, 25-32, 25 citations
M. Yamada, Y. Ohta, G. Bachmanova, Y. Nishimoto, A. Archakov, and S. Kawato
"Dynamic Interactions of Rabbit Liver Cytochromes P450IA2 and P450IIB4 with Cytochrome b5 and NADPH-Cytochrome P450 Reductase in Proteoliposomes"
Biochemistry (1995) 34, 10113-10119 [PDF], 35 citations
Y. Ohta, M. Yamada and S. Kawato
"Dynamic Topology and Electron Transfer Interactions of Microsomal Cytochrome P450 in Liver andAdrenal Cortex: Protein Rotation Study"
Cytochrome P450: Biochemistry, Biophysics and Molecular Biology (1994) pp. 889-892, John Libbey,Eurotext, Paris
Y. Ohta, T, Sakaki, Y, Yabusaki, H, Ohkawa, and S. Kawato
"Rotation and Membrane Topology of Genetically Expressed Methylcholanthrene-inducible CytochromeP-450IA1 Lacking the N-terminal Hydrophobic Segment in Yeast Microsomes"
J. Biol. Chem. (1994) 269, 15597-15600 [PDF], 26 citations
S. Kominami, H. Tagashira, Y. Ohta, M. Yamada, S. Kawato, and S. Takemori
"Membrane Topology of Bovine Adrenocortical Cytochrome P-450C21: Structural Studies by Trypsin Digestion in Vesicle Membranes"
Biochemistry (1993) 32, 12935-12940 [PDF], 18 citations
Y. Ohta, S. Kawato, H. Tagashira, S. Takemori, and S. Kominami
"Dynamic Structures of Adrenocortical Cytochrome P-450 in Proteoliposomes and Microsomes: Protein Rotation Study"
Biochemistry (1992) 31, 12680-12687 [PDF], 55 citations
Y. Ohta and S.Kawato
"Dynamic Membrane Topology of Microsomal Cytochrome P-450"
J. of Basic & Clin. Physiol. & Pharmacol. (1992) pp.119
K. Tanji, Y. Ohta, S. Kawato, S. Natori, and K. Sekimizu
"Decrease by Phychotropic Drugs and Local Anesthetics of Membrane Fluidity Measured by Fluorescence Anisotropy in Escherichia coli"
J. Pharm. Pharmacol. (1992) 44, 1036-1037, 31 citations
M. Kawakita, Y. Imamura, H. Yamamoto, S. Suzuki, and S. Kawato
"Structural Basis for the Molecular Mechanisms of the Calcium-Transporting ATPase of the Sarcoplasmic Reticulum"
New Era of Bioenergetics (1991) pp 47-72, Academic Press, Tokyo
S. Kawato and Y. Ohta
"Electron Transfer Interactions of Cytochrome P-450 in Liver and Adrenal Cortex Membranes"
Cytochrome P-450: Biochemistry and Biophysics (1991) pp 222-227
T. Iwase, T. Sakaki, Yabusaki, H. Ohkawa, Y. Ohta, and S. Kawato
"Rotation and Interactions of Genetically Expressed Cytochrome P-450 in Yeast Microsomes"
Biochemistry (1991) 30, 8347-8351 [PDF], 24 citations
H. Etter, C. Richter, Y. Ohta, K.H. Winterhalter, H. Sasabe, and S. Kawato
"Rotation and Interactions with Epoxide Hydrase of Cytochrome P-450 in Proteoliposomes"
J. Biol. Chem. (1991) 266, 18600-18605 [PDF], 33 citations
Y. Ohta, K. Yanagibashi, T. Hara, M. Kawamura, and S. Kawato
"Protein Rotation Study of Cytochrome P-450 in Submitochondrial Particles: Effect of KCl and Intermolecular Interactions with Redox Partners"
J. Biochem. (1991) 109, 594-599, 18 citations
S. Kawato, I. Ashikawa, T. Iwase, and E. Hara
"Drug-induction Decreases the Mobility of Cytochrome P-450 in Rat Liver Microsomes: Protein Rotation Study"
J. Biochem. (1991) 109, 587-593, 18 citations
Y. Miura, S. Kawato, T. Iwase, S. Ohta, and M. Hirobe
"Effects of Oxygen on the Relative Photodissociability of Cytochrome P-450\CO Complex in Rat Liver Microsomes"
Biochemistry (1991) 30, 3395-3400 [PDF]
S. Kawato, in Biomedical Optics (1991) vol.1429, p.127-131, SPIE "Visualization of Electron Transfer Interactions of Membrane Proteins"
S. Komura, Y. Ohta, S. Kawato
"A Theory of Optical Anisotropy Decay in Membranes"
J. Phys. Soc. Japan (1990) 59, 2584-2595
Y. Ohta, F. Mitani, Y. Ishimura, K. Yanagibashi, M. Kawamura and S. Kawato
"Cytochrome P-450-containing Protein-Protein Interactions in Bovine Adrenocortical Mitochondria"
J. Pharmacobio-Dyn. (1990) 13, 112
Y. Ohta, F. Mitani, Y. Ishimura, K. Yanagibashi, M. Kawamura, and S. Kawato
"Conversion of Cholesterol to Pregnenolone Mobilizes Cytochrome P-450 in the Inner Membrane of Adrenocortical Mitochondria: Protein Rotation Study"
J. Biochem. (1990) 107, 97-104, 18 citations
S. Suzuki, S. Kawato, T. kouyama, K. Kinosita, Jr., A. Ikegami, and M. kawakita
"Independent Flexible Motion of Submolecular Domains of the Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum Measured by Time-Resolved Fluorescence Depolarization of Site-Specificaly Attached Probes"
Biochemistry (1989) 28 ,7734-7740 [PDF], 18 citations
S. Kawato, F. Mitani, T. Iizuka, Y. Ishimura
"Rotation and Protein-Protein Interactions of Cytochrome P-450 in the Inner Membrane of Adrenocortical Mitochondria"
J. Biochem. (1988) 104, 188-191, 22 citations
J. Gut, S. Kawato, R.J. Cherry, K.H. Winterhalter and C. Richter
"Lipid Peroxidation Decreases the Rotational Mobility of Cytochrome P-450 in Rat Liver Microsomes"
Biochim. Biophys. Acta (1985) 817, 217-228, 53 citations
K. Kinosita, Jr., S. Kawato and A. Ikegami
"Dynamic Structure of Biological and Model Membranes: Analysis by Optical Anisotropy Decay Measurement"
Adv. Biophys. (1984) Vol.17, p.147-203, 110 citations
M. Mueller, J.J.R. Krebs, R.J. Cherry and S. Kawato
"Rotational Diffusion of the ADP/ATP Translocator in the Inner Membrane of Mitochondria and in Proteoliposomes"
J. Biol. Chem. (1984) 259, 3037-3043 [PDF], 33 citations
S. Kawato
"Rotational Diffusion of the ADP/ATP Translocator in the Inner Membrane of Mitochondria and in Proteoliposomes"
Proceedings of the 9th International Taniguchi Symposium (1983) p.416-433
J. Gut, C. Richter, R.J. Cherry, K.H. Winterhalter and S. Kawato
"Rotation of Cytochrome P-450: Complex Formation of Cytochrome P-450 with NADPH-Cytochrome P-450 Reductase in Liposomes Demonstrated by Combining Protein Rotation with Antibody-induced Crosslinking"
J. Biol. Chem. (1983) 258, 8588-8594 [PDF], 75 citations
S. kawato
"Rotational Diffusion Analysis of Rat Liver Cytochrome P-450 Systems"
Liver and Aging (1982) p.12-13, Elsevier/North-Holland
A. Ikegami, K. Kinosita,Jr., T. Kouyama and S. Kawato
"Structure and Dynamics of Biological Membranes Studied by Nanosecond Fluorescence Spectroscopy"
Structure, Dyanmics and Bioenergesis of Biomembranes (1982) p.1-31, Japan Scientific Societies Press
S. Kawato, C. Lehner, M. Muller and R.J. Cherry
"The Effect of Liposome Fusion on Protein-protein Interactions of Cytochrome Oxidase in Inner Mitochondrial Membranes"
International Workshops on Membrane and Transport in Biosystems (1982) p.53, Laterza Lipostampa
M. Mueller, R.J. Cherry and S. Kawato
"Rotational Mobility of the ADP/ATP Translocator in the Inner Mitochondrial Membrane"
IUB-IUPAB Bioenergetics group (1982) p.179-180, LBTM-CNRS Edition, Villeurbanne
K. Eichenberger, P. Boehni, K.H. Winterhalter, S. Kawato and C. Richter
"Microsomal Lipid Peroxidation Causes an Increase in the Order of the Membrane Lipid Domain"
FEBS Lett. (1982) 142, 59-62, 171 citations
S. Kawato, C. Lehner, M. Muller and R.J. Cherry
"Protein-protein Interactions of Cytochrome Oxidase in Inner Mitochondrial Membranes: The Effect of Liposome Fusion on Protein Rotaitonal Mobility"
J. Biol. Chem. (1982) 257, 6470-6476 [PDF], 49 citations
J. Gut, C. Richter, R. J. Cherry, K.H. Winterhalter and S. Kawato
"Rotation of Cytochrome P-450 II: Specific Interactions of Cytochrome P-450 with NADPH-cytochrome P-450 Redcutase"
J. Biol. Chem. (1982) 257, 7030-7036 [PDF], 91 citations
S. Kawato, J. Gut, R.J. Cherry, K.H. Winterhalter and C. Richter
"Rotation of Cytochrome P-450 I: Protein-protein Interactions of Cytochrome P-450 in Liver Microsomes and Phospholipid Vesicles"
J. Biol. Chem. (1982) 257, 7023-7029 [PDF], 112 citations
K. Kinosita, Jr., A. Ikegami and S. Kawato
"On the Wobbling in Cone Analysis of Fluorescence Anisotropy Decay"
Biophys. J. (1982) 37, 461-464, 200 citations
M. Muller, J.J.R. Krebs, R.J. Cherry and S. Kawato
"Selective Labeling and Rotational Diffusion of the ADP/ATP-Translocator in the Inner Mitochondorial Membrane"
J. Biol. Chem. (1982) 257, 1117-1120 [PDF], 46 citations
S. Kawato, C. Lehner, M. Mueller and R.J. Cherry
"Modualtion of Protein-protein Interactions of Cytochrome Oxidase by Liposome-Mitochondrial Inner Membrane Fusion: Protein Rotation Study"
Vectorial Reactions in Electron and Ion Transport in Mitochondria and Bacteria (1981) p.111-114, Elsevier/North-Holland
K. Kinosita, Jr., S. Kawato, A. Ikegami, S. Yoshida and Y. Orii
"The Effect of Cytochrome Oxidase on Lipid Chain Dynamics : A Nanosecond Fluorescence Depolarization Study"
Biochem. Biophys. Acta (1981) 647, 7-17, 51 citations
S. Kawato, E. Siegel, E. Carafoli and R.J. Cherry
"Rotation of Cytochrome Oxidase in Phospholipid Vesicles: Investigations of Interactions between Cytochrome Oxidase and between Cytochrome Oxidase and Cytochrome bc1 Complex"
J. Biol. Chem. (1981) 256, 7518-7527 [PDF], 90 citations
S. Kawato, R.J. Cherry, and P.R. McIntosh
"Rotational-Diffusion and Cross-Linking Studies of Cytochrome P-450 in Rabbit Liver Microsomal Membranes"
Biochemical Society Transactions (1981) 85-86
S. Kawato, S. Yoshida, Y. Orii, A. Ikegami and K. Kinosita, Jr.
"Nanosecond Time-resolved Fluorescene Investigations of Temperature-induced Conformational Changes in Cytochrome Oxidase in Phosphatidylcholine Vesicles and Solubilized Systems"
Biochem. Biophys. Acta (1981) 634, 85-92, 17 citations
P.R. McIntosh, S. Kawato, R.B. Freedman and R.J. Cherry
"Evidence from Criss-linking and Rotational Diffusion Studies that Cytochrome P-450 can form Molecular Aggregates in Rabbit-liver Microsomal Membranes"
FEBS Lett. (1980) 122, 54-58, 45 citations
S. Kawato and K. Kinosita, Jr.
"Time Dependent Absorption Anisotropy and Rotational Diffusion of Protein in Membtanes"
Biophys. J. (1980) 36, 277-296, 92 citations
S. Kawato, E. Siegel, E. Carafoli and R. Cherry
"Cytochrome Oxidase Rotates in the Inner Membrane of Intact Mitochondria and Submitochondrial Particles"
J. Biol. Chem. (1980) 255, 5508-5510 [PDF], 65 citations
S. Kawato, A. Ikegami, S. Yoshida and Y. Orii
"Fluorescent Probe Study of Temperature-induced Conformational Changes in Cytochrome Oxidase in Lecithin Vesicles and Solubilized Systems"
Biochemistry (1980) 19, 1598-1603 [PDF], 22 citations
S. Yoshida, Y. Orii, S. Kawato and A. Ikegami
"Effects of Temperature on Cytochrome Oxidase Activity in Solubilized Form and Lipid Vesicle Systems"
J. Biochem. (1979) 86, 1443-1450
S. Kawato, A. Ikegami, S. Yoshida and Y. Orii
"Fluorescent Probe Study of Temperature-induced Conformational Changes in Cytochrome Oxidase in Lecithin Vesicles and Solubilized Systems"
Cytochrome Oxidase (1979) p.241-250, Elsevier North-Holland, Amsterdam
S. Yoshida, Y. Orii, S. Kawato and A. Ikegami
"Effects of Temperature on Cytochrome Oxidase Activity - A New Proposal for The Arrhenius Break Mechanism of Mitochondrial Cytochrome Oxidase Activity"
Cytochrome Oxidase (1979) p.231-240, Elsevier North-Holland, Amsterdam
S. Kawato, K. Kinosita, Jr. and A. Ikegami
"Effect of Cholesterol on the Molecular Motion in the Hydrocarbon Region of Lecithin Bilayers Studied by Nanosecond Fluorescence Techniques"
Biochemistry (1978) 17, 5026-5031 [PDF], 158 citations
1977
K. Kinosita, Jr., S. Kawato and A. Ikegami
"A Theory of Fluorescence Polarization Decay in Membranes"
Biophys. J. (1977) 20, 289-305[PDF], 1080 citations
S. Kawato, K. Kinosita, Jr. and A. Ikegami
"Dynamic Structure of Lipid Bilayers Studied by Nanosecond Fluorescence Techniques"
Biochemistry (1977) 16, 2319-2324[PDF], 455 citations
International Meetings (* Invited Talks)
2023
S Kawato, M Soma and M Ogiue-Ikeda
"Hippocampus-synthesized estrogen and androgen rapidly modulate dendritic spines and LTP in non-genomic manner"
Society for Neuroscience, Annual Meeting, Washington, USA, 2023 Nov Poster[PDF]
Video[mp4]
2022
S Kawato, M Soma and M Ogiue-Ikeda
"Advantages of hippocampus-synthesized estrogen and androgen in rapid non-genomic modulation of dendritic spines and LTP"
Steroids and Nervous System, Virtual Meeting, Torino, Italy, 2022 Feb
S Kawato, M Soma and M Ogiue-Ikeda
"Hippocampus-synthesized estrogen and androgen rapidly modulate dendritic spines and LTP in non-genomic manner"
Society for Neuroscience, Annual Meeting, San Diego, USA, 2022 Nov
2021
S Kawato, M Soma and M Ogiue-Ikeda
"Hippocampus-synthesized estrogen and androgen rapidly modulate dendritic spines and LTP in non-genomic manner"
Society for Neuroscience, Virtual Meeting, Chicago, USA, 2021 Nov
2020
S Kawato, M.Soma and M Ogiue-Ikeda
"Hippocampus-synthesized estrogen and androgen modulate dendritic spines and LTP in non-genomic manner"
Steroids and Nervous System, Virtual Meeting, Torino, Italy, 2021 Feb
2018
M Soma, M Ikeda, S Kawato
"Non-genomic modulation of synapses by hippocampus-synthesized androgen, estrogen and stress steroids" (Organized Poster Session)[PDF]
Society for Neuroscience, Annual Meeting, San Diego, USA, 2018
2017
S. Kawato, Y. Komatzuzaki, M. Soma
"Hippocampus-synthesized estrogen and androgen modulate dendritic spines and LTP in non-genomic manner"
Society for Neuroscience, Annual Meeting, Washington, USA, 2017
(*) S. Kawato
"Rapid non-genomic signaling of androgen, estrogen and corticosterone is mediated by kinases in the hippocampus "
9th International Meeting of STEROIDS AND NERVOUS SYSTEM, Torino, Italy, Feb, 2017
2016
S. Kawato
"Estrogen rapidly modulates spinogenesis in the hippocampus,via synaptic estrogen receptor and kinase neoworks"
17th International Congress of Endocrinology, Beijin, China, Sep, 2016
2014
(*) Kawato S and Chung BC
"Analysis of neurosteroid effects on hippocampal neural circuits using novel multi-electrode probe methods"
Taiwan-Japan Workshop on Bioelectronics and Biophotonics, Tokyo, Japan, 2014
S. KAWATO, Y. HOJO, Y. HASEGAWA, H. MUKAI
"Hippocampus-synthesized estrogen and androgen rapidly modulate dendritic spines and LTP"
Society for Neuroscienece, Annual Meeting, Washington USA, 2014
2013
S. KAWATO, Y. HOJO, Y. OOISHI, H. MUKAI, M. YOSHIYA
"Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines"
Society for Neuroscienece, Annual Meeting, San Diego, California, 2013
2012
H. MUKAI, Y. HATANAKA, K. MITSUHASHI, Y. HOJO, R. KOMATSUZAKI, R. SATO, G. MURAKAMI, S. KAWATO
"Mathematical and automated analysis of dendritic spines from confocal laser microscopy images"
Society for Neuroscienece, Annual Meeting, New Orleans USA, 2012
S. KAWATO, Y. HOJO, H. MUKAI, Y. OOISHI
"Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines"
Society for Neuroscienece, Annual Meeting, New Orleans USA, 2012
2011
S. KAWATO, Y. HOJO, Y. OOISHI, S. HIGO, H. MUKAI
"Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines"
Society for Neuroscienece, Annual Meeting, Washington USA, 2011
T. YAMAZAKI, M. YAMAMOTO, S. KOMATSU, M. ONIZAKI, S. KAWATO, T. MUKUDA, A. ISHIDA
"Neuroprotective effect of hippocampus-synthesized estradiol against neurotoxicity of methylmercury"
Society for Neuroscienece, Annual Meeting, Washington USA, 2011
2010
S. KAWATO, Y. HOJO1, S. HIGO1, R. SATO1, H. MUKAI1, G. MURAKAMI
"Synthesis of estrogen and androgen which rapidly modulate spines and LTD/LTP in the hippocampusy"
Society for Neuroscienece, Annual Meeting,San Diego USA, Nov, 2010
2009
S. KAWATO, H. MUKAI, Y. HOJO, Y. HATANAKA, S. HIGO, G. MURAKAMI, Y.OOishi, T. KIMOTO, T. KOMINAMI
"Rapid modulation of spines and LTD/LTP by estrogen and androgen in rat hippocampus: neuro-intracrinology"
Society for Neuroscienece, Annual Meeting,Chicago USA, Oct, 2009
Hojo Y, Higo S, Mukai H, Murakami G, Kominami S, Harada N, Honma S, Kimoto T, Kawato S
"Neurosteroid synthesis and synaptocrinology in the hippocampal synapses"
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Jul. 2009
Mukai, H., Hatanaka, Y., Sato, R., Ooishi, Y., Ogiue-Ikeda, M., Hojo, Y., Kominami, S., Kawato, S
"Rapid modulation of synaptic plasticity by hippocampal-derived sex-steroids"
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Jul. 2009
2008
(*) Kawato S, Mukai H, Hojo Y, Murakami G, Higo S, Hatanaka Y, Kimoto T
"Rapid modulation of synaptic plasticity by hippocampus-derived estrogens: Synaptocrinology"
US/Japan Neurosteroid Symposium, Gifu, Japan, September, 2008
Hojo Y, Higo S, Mukai H, Murakami G, Kominami S, Yamazaki T, Harada N, Honma S, Kimoto T, Kawato S
"Neurosteroid synthesis and synaptocrinology in the hippocampal synapses"
US/Japan Neurosteroid Symposium, Gifu, Japan, September, 2008
Higo S, Mukai H, Ogiue-Ikeda M, Murakami G, Kawato S
"Synaptic localization of estrogen receptor and its rapid action on synaptic plasticity of rat hippocampus"
US/Japan Neurosteroid Symposium, Gifu, Japan, September, 2008
(*) Kawato S, Mukai H, Murakami G, Hojo Y, Hatanaka Y, Higo S, Kimoto T
"Rapid modulation of spines and LTD/LTP by estradiol in rat hippocampus: neuro-synaptocrinology"
Society for Neuroscienece 38th Annual Meeting,. Washington DC, U.S.A., November, 2008
2007
(*) Kawato S, Hojo Y, Ishii H, Tsurugizawa T, Mukai H, Ogiue-Ikeda M, Kimoto T
"SYNAPTOCRINOLOGY: LOCAL BRAIN SYNTHESIS OF ESTROGENS AND ANDROGENS WITH PARACRINE ACTIVITY"
27th INTERNATIONAL EPILEPSY CONGRESS, Singapore, July 2007
(*) Kawato S., Ogiue-Ikeda M., Tanabe N., Tsurugizawa T., Hojo Y., and Mukai H.
"RAPID MODULATION OF LONG-TERM DEPRESSION AND SPINOGENESIS BY ENDOCRINE DISRUPTERS IN ADULT RAT HIPPOCAMPUS"
4th International Meeting of STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 2007
2006
(*) Kawato S., Tsurugizawa T., Ogiue-Ikeda M., Hojo Y. Mukai H.
"Rapid modulation of hippocampal LTD by estrogen and endocrine disrupters: multielectrode analysis"
Network Physiology Symposium, Society for Neuroscienece 35th Annual Meeting, Atlanta, U.S.A., October, 2006
(*) Kawato S, Hojo Y, Ishii H, Tsurugizawa T, Mukai H, Kimoto T, Ogiue-Ikeda M
"Local neurosteroid production in the hippocampus: essential for synaptic plasticity of memory"
International Congress of Neuroendocrinology 2006, Pittsburgh, USA June, 2006
Hojo Y., Nakajima K., Nakanishi H., Higo S., Ishii H., Mukai H., Morrison J. H., Janssen W. G. M., Kominami S., Harada N., Kimoto T. and Kawato S.
"Synthesis of brain steroids and localization of P450s in the hippocampal neurons."
20th IUMUB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congres, Kyoto, Japan June 2006
Inoue N., Ogiue-Ikeda M., Takata N., Nakajima K. and Kawato S.
"Effects of sex steroid and endocrine disrupters on rat hippocampal synapses: Multi-electrode analysis"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Hatanaka Y., Tsurugizawa T., Tanabe N. and Kawato S.
"Acute morphological effects of sex steroids and endocrine disruptors in hippocampal dendritic spines"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Higo S., Hojo Y., Ishii H. and Kawato S.
"Androgen and estrogen synthesis in the rat hippocampus"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Hojo Y., Nakajima K., Nakanishi H., Higo S., Ishii H., Mukai H., Morrison J. H., Janssen W. G. M., Kominami S., Harada N., Kimoto T. and Kawato S.
"Synthesis of brain steroids and localization of P450s in the hippocampal synapses."
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Mukai H., Kominami S., Murakami G., Janssen W.G.M., Morrison J.H. and Kawato S.
"Synaptic Localization of Estrogen Receptor alpha in the Rat Hippocampus"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Murakami G., Kominami S., Mukai H., Kimoto T. and Kawato S.
"The distribution of estrogen receptor in the hippocampus"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Ooishi Y. and Kawato S.
"Neurosteroids rapidly modulate the activity of hippocampal neurons at CA1 region"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Fujiwara M., Murakami G., Mukai H. and Kawato S.
"Immunohistochemical localization of steroidogenic enzymes in the rat hippocampus"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
Komatsuzaki Y., Murakami G., Nakanishi H., Hojo Y. and Kawato S.
"Rapid morphological changes of dendritic spines mediated by glucocorticoid receptor (GR) in rat hippocampus"
5th East Asian Biophysics Symposium and 45th Annual Meeting of the Biophysical Society of Japan, Okinawa, Japan November 2006
2005
(*) S. Kawato, H. Ishii, H. Mukai, Y. Hojo, T. Tsurugizawa, M. Ogiue-Ikeda and T. Kimoto
"Brain Cytochrome P450: Local Neurosteroid Synthesis in Hippocampal Neurons Plays an Essential Role in Synaptic Plasticity of Memory"
13th Meeting of International Society for the Study of Xenobiotics, Maui, U.S.A., October, 2005
H. Ishii, Y. Sonoki, A. Furukawa, Y. Hojo, T. Kimoto and S. Kawato
"The neuron is a steroid hormone factory. - Biosynthesis of androgen and estrogen from cholesterol in the hippocampus"
21st Century COE 2nd International Symposium, Tokyo, Japan, March, 2005
H. Mukai, G. Murakami, Y. Hojo and S. Kawato
"Expression of synaptic estrogen receptors in hippocampal neurons"
21st Century COE 2nd International Symposium, Tokyo, Japan, March, 2005
N. Takata, M. Ogiue-Ikeda and S. Kawato
"Multi-site recording of neuronal activities in the hippocampus"
21st Century COE 2nd International Symposium, Tokyo, Japan, March, 2005
T. Tsurugizawa, N. Tanabe, T. Kimoto, Y. Hojo and S. Kawato
"Local Synthesis and Rapid Action of Brain Estrogens in Adult Rat Hippocampus: From Neuro-endocrinology to Neuro-synaptocrinology"
3rd International Meeting of STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 2005
Y. Hojo, T. Enami, K. Nakajima, A. Furukawa, H. Ishii, H. Mukai, J.H. Morrioson, W.G.M. Janssen, Ho. Tamura, S. Kominami, N. Harada, T. Kimoto and S. Kawato
"Synthesis of brain neurosteroids and localization of P450s in the hippocampal neurons of adult male rats"
3rd International Meeting of STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 2005
T. Kimoto, G. Murakami, N. Takata, H. Mukai, M. Ogiue-Ikeda, Y. Ooishi, Y. Hojo, S. Kominami, J.H. Morrison, W.G.M. Janssen and S. Kawato
"Acute effect of brain neurosteroids on the hippocampal neurons of adult male rats"
3rd International Meeting of STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 2005
2004
T. Kimoto
"Local synthesis and action of estrogen in the hippocampal neurons"
The 8th MEMBRANE RESEARCH FORUM, INTERNATIONAL SYMPOSIUM ON NANO-MECHANOBIOTECHNOLOGY OF SUPURAMOLECULAR COMPLEXES, Nagoya, Japan, November, 2004
H. Mukai, G. Murakami, S. Kominami, J. H. Morrison, W.G.M. Janssen, P. Chambon, S. Kato and S. Kawato
"Synaptic localization of estrogen receptor alpha in the hippocampal pyramidal and granule neurons of adult male rat"
Society for Neuroscience 34th Annual Meeting, San Diego, California, U.S.A., October, 2004
N. Takata, M. Ogiue-Ikeda, Y. Ooishi and S. Kawato
"Non-genomic rapid effects of estradiol and a xenoestrogen on rat hippocampal synapses: Multi-electrode dish analysis"
Society for Neuroscience 34th Annual Meeting, San Diego, California, U.S.A., October, 2004
2003
(*) S. Kawato and N. Takata
"Rapid modulation of hippocampal neuronal plasticity by brain estrogen and endocrine disrupters (EDs): an electrophysiological analysis"
Network Physiology Symposium, Society for Neuroscienece 33rd Annual Meeting, New Orleans, Louisiana, U.S.A., November, 2003
(*) S. Kawato
"Rapid Action and Local Synthesis of Neurosteroids in the Brain Hippocampus: Their Role in Synaptic Transmission and Learning and Memory"
4th East Asian Biophysics Symposium, Taiwan, November, 2003
N. Takata, Y. Hojo, T. Nozawa, H. Mukai and S. Kawato
"The role of neurosteroids and xenoestrogens in rat hippocampal synapses"
Society for Neuroscienece 33rd Annual Meeting, New Orleans, Louisiana, U.S.A., November, 2003
Y. Hojo, T. Enami, M. Watanabe, T. Kimoto & S. Kawato
"Brain Neurosteroids 2: Rapid action on the learning and memory"
21st Century COE 1st International Sympodium, Komaba, Tokyo Nov. 2003
H. Mukai, G. Murakami, H. Ishii, Y. Hojo & S. Kawato
"Expression of neurosteroidogenic enzymes and estrogen receptors in hippocampal neurons"
21st Century COE 1st International Sympodium, Komaba,Tokyo Nov. 2003
T. Nozawa, N. Takata, N. Tanabe, T. Tsurugizawa, A. Kawata & S. Kawato
"Brain Neurosteroid 1: Synthesis in the hippocampal neurons"
21st Century COE 1st International Sympodium, Komaba,Tokyo Nov. 2003
(*) Suguru Kawato, [Special Lecture]
"Imaging analysis on action and synthesis of neurosteroids in brain hippocampal neurons."
New Development in Radiation Biology(Riken, Japan). June 26, 2003
2002
N. Takata, T. Harada, M. Okabe & S. Kawato,
"Imaging analysis of nitric oxide (NO) production in hippocampus indeced upon NMDA-, tetanus-stimulation using newly synthesized NO reactive dye, DAR-4M"
Society for Neuroscience 32nd Annual Meeting, Orlando, FL. Nov. 2002
(*) Suguru Kawato
"Hippocampal neurosteroids such as female hormone modulate acutely neuron-neuron communication"
5th Membrane Forum, Nagoya, Japan 2002
2001
H. Mukai, N. Takata, S. Uchino & S. Kawato,
"Effect of neurosteroid, pregnenolone sulfate, on Ca2+ signaling through NMDA receptors expressed in CHO cells and on NO production in hippocampal slices."
Society for Neuroscience 31st Annual Meeting, San Diego, Calif. Nov. 2001
(*) S. Kawato, T. Kimoto & Y. Hojo,
"Synthesis and acute action of neurosteroid in rat hippocampal neurons: NMDA-and Ca-dependent processes."
Society for Neuroscience 31st Annual Meeting, San Diego, Calif. Nov. 2001
(*) Suguru Kawato
"Neurosteroids are paracrine messengers in the brain"
12th International Conference on Cytochrome P450, France. September, 11 2001
2000
(*) Suguru Kawato
"Brain hippocampal cytochrome P450scc system: synthesis and action of neurosteroids"
International Workshop of P450 : From Sequence to Function, Moscow, Russia. July 6-10, 2000
~1999
Takahashi, T. Takata, N., Kimoto, T., Kawato, S. International Symposium on Molecular Steroidogenesis, Nara, Japan, (1999) "Corticosterone prolonged NMDA-induced Ca2+ signaling in rat hippocampal neurons"
Takata, N., Kimoto, T., Takahashi, T., Kojima, T., Kominami, S., Nagano, T., Kawato, S. International Symposium on Molecular Steroidogenesis, Nara, Japan, (1999) "Steroids potentiate nitric oxide production in rat hippocampal CA1 region: real-time fluorescence microscopic imaging"
Ichikawa, T., Yamada, M., Suzuki, K., Kimoto, T., Kawato, S. International Symposium on Molecular Steroidogenesis, Nara, Japan, (1999) "ACTH facilitates the intracellular transport of low density lipoprotein in bovine adrenocortical cells"
Yamada, M., Homma, R., Kimoto, T., Kawato, S. International Symposium on Molecular Steroidogenesis, Nara, Japan, (1999) "Fluorescence analysis for regulation of cytochrome P450scc activity on steroidogenic stimulation in adrenocortical cells"
Kimoto, T., Ohta, Y., Makino, J., Tsurugizawa, T., Kawato, S. International Symposium on Molecular Steroidogenesis, Nara, Japan, (1999) "Localization of functional neurosteroidogenic system in pyramidal neurons in the rat brain hippocampus."
Yamada, M., Kimoto, T., Homma, R., Kawato, S. 12th International Symposium on Microsomes and Drug Oxidations, Montpellier, France, (1998) "Topological localization of CYT. P450 and transient association with redox partners in Membranes: Protein rotation study."
Kimoto, T., Asou, H., Ohta, Y., Nishimura, D., Bettou, T. and Kawato, S., The 3rd Hamamatsu Symposium on Biomolecular Mechanisms and Photonics: Cell-Cell Communication, Hamamatsu, (1997) "Fluorescence imaging of elementary steps for neurosteroid synthesis in brain glial cells"
Bettou, T., Kimoto, T., Mukai, H., Ohta, Y. and Kawato, S., The 3rd Hamamatsu Symposium on Biomolecular Mechanisms and Photonics: Cell-Cell Communication, Hamamatsu, (1997) "Digital fluorescence imaging of rapid sliding of LDL-containing endosomes in adrenocortical cells and glial cells"
Yamada, M., Homma, R., Ohta, Y., and Kawato S. , 8th International Conference on Bioinorganic Chemistry, Yokohama, Japan, (1997) "Electron Transfer Interactions of Mitochondrial Cytochrome P450 in Membranes"
T. Kimoto, H. Mukai, R. Homma, T. Bettou, D. Nishimura, Y. Ohta and S. Kawato, Keio International Symposium of Life Sciences and Medicine, Tokyo (1996) "Imaging of Calcium Oscillations and Activity of Cytochrome P450scc in Adrenocortical Cells."
Kimoto, T., Mukai, H., Ohta, Y., Yamada, M., and Kawato, S., in 10th International Symposium on Microsomes and Drug Oxidations, Los Angeles, U. S. A.(1996) "Calcium Oscillations, Motion and Activity of Cytochrome P450 in Adrenal Cells"
Homma, R., Yamada, M. Ohta, Y. and Kawato, S., International Congress on Membranes and Membrane Processes, Yokohama, (1996) "Dynamic Protein Interactions and Topology of Mitochondrial and Microsomal Cyt. P450 in Membranes"
Ohta, Y., Yamada, M., Kimoto, T., Kubota, H., and Kawato, S., 9th International Conference on Cytochrome P450, Zurich, (1995) "Transient Association with Redox Partners and Topology of Cytochrome P450 in Membranes"
Yamada, M., Kubota, H., Chernogolov, A., Ohta, Y., Kimoto,T., and Kawato, S., The 2nd Hamamatsu Symposium on Biomolecular Mechanisms and Photonics: Cell-Cell Communication, Hamamatsu, (1995) "Protein Rotation Study and Fluorescence Imaging for Intracellular Signaling for Steroidogenesis in Adrenal Cortex"
International Symposium of Analytical Pharmacology, Ohsaka (1996) "Functional Imaging of Calcium Oscillations,LDL and Cytochrome P450 in Adrenocortical and Glial Cells"
T. Kimoto, H. Mukai, Y. Ohta, M. Yamada and S. Kawato, XIth International Symposium on Microsomes and Drug Oxidations, Los Angels, USA (1996) "Calcium Oscillations, Motion and Activity of Cytochrome P450 in Adrenal Cells"
Y. Ohta, M. Yamada,T. Kimoto, H. Kubota, and S. Kawato, 9th International Conference on Biochemistry and Biophysics and Molecular Biology of Cytochrome P-450, Zurich, Switzerland (1995) "Transient Association with Redox Partners and Topology of Cytochrome P-450 in Membranes"
T. Kimoto, Y. Ohta, and S. Kawato, 2nd Hamamatsu International Symposium on Cell-Cell Communications, Hamamatsu (1995) "Multi-view Imaging of Calcium Signaling and Distribution of Steroidogenic Enzymes in Adrenal Fasciculata Cells"
Y. Ohta, M. Yamada, and S. Kawato, 10th International Symposium on Microsomes & Drug Oxidations, Tronto, p 447 (1994) "Dynamic Protein Interactions and Topology of Cytochrome P-450 in Membranes"
Y. Ohta, and S. Kawato, First East Asian Symposium on Biophysics, Hyogo, (1994) "Measurements of Cellular Response of Adrenocortical Fasciculata cells"
Y. Ohta, , M., Yamada, and S. Kawato, 8th International Conference on Cytochrome P450: Biochemistry, Biophysics and Molecular Biology, Lisbon, "Dynamic Topology and Electron Transfer Interactions of Microsomal Cytochrome P450 in Liver and Adrenal Cortex: Protein Rotation Study"
M., Yamada, Y. Ohta, ,and S. Kawato, 2nd Symposium of Cytochrome P450 in Microorganisms and Plants, Tokyo (1993)
Y. Ohta and S.Kawato, 9th International Symposium on Microsomes and Drug Oxidations, Israel (1992) "Dynamic Membrane Topology of Microsomal Cytochrome P-450"
(*) S. Kawato, 7th International Conference on Biochemistry and Biophysics of Cytochrome P-450, Moscow (1991) Plenary Lecture, "Electron Transfer Interactions of Cytochrome P-450 in Liver and Adrenal Cortex Membranes"
(*) S. Kawato and Y. Ohta, International Symposium of Energy Conversion Science, Kanagawa (1991) "Electron Transfer Interactions of Cytochrome P-450 in Adrenal Cortex and Liver"
(*) S. Kawato, SPIE Congress on Biomedical Optics, Los Angels (1991) Plenary Lecture, "Visualization of Electron Transfer Interactions of Membrane Proteins"
(*) S. Kawato,Y. Ohta,T. Iwase, Y. Ishimura, K. Yanagibashi, T. Sakaki, H. Ohkawa, 10th International Biophysics Congress, Vancouver (1990) "Electron Transfer Interactions of P-450 in Adrenal Cortex and Liver"
H. Etter, Y. Ohta, C. Richter, K.H. Winterhalter and S. Kawato, Microsomes and Drug Oxidations, Stokholm (1990) "Intermolecular Interactions of Liver Cytochrome P-450 with Epoxide Hydrase in Proteoliposomes Studied by Protein Rotation Measurements"